radioiodine therapy for hyperthyroidism
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abstract
radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of hyperthyroidism. the method employed in this research was a systematic bibliographic review, in which only valid studies or the clinically detailed enough open-labeled studies using validated scales were used. iodine-131 (i-131) acts by the destructive effect of short-range beta radiation on thyroid cells. indications for radioiodine therapy include toxic nodules (in which i-131 is the first choice of treatment), recurrent hyperthyroidism after antithyroid treatment or surgery, intolerance to antithyroid therapy due to side-effects and patient preference. due to difficulties in previous methods for dose determination, fixed dose method of i-131 is now considered the best practical method for radioiodine therapy in primary hyperthyroidism. absolute contraindications for radioiodine treatment are pregnancy and lactation. in pediatric patients, radioiodine therapy can be used, but is mainly considered in recurrent toxic goiter and when antithyroid medication is ineffective. there is no clear evidence indicative of carcinogenic or teratogenic effect of this agent.
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Radioiodine therapy for hyperthyroidism
Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of hyperthyroidism. The method employed in this research was a systematic bibliographic review, in which only valid studies or the clinically detailed enough open-labeled studies using validated scales were used. Iodine-131 (I-131) acts by the destructive effect of short-range beta radiation on ...
full textRadioiodine therapy for hyperthyroidism.
n engl j med 364;6 nejm.org february 10, 2011 542 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are presen...
full textRadioiodine therapy for hyperthyroidism
Radioiodine therapy is the safest, simplest, least expensive and most effective method for treatment of hyperthyroidism. The method employed in this research was a systematic bibliographic review, in which only valid studies or the clinically detailed enough open-labeled studies using validated scales were used. Iodine-131 (I-131) acts by the destructive effect of short-range beta radiation on ...
full textEvaluation of Radioiodine Therapy in the Refractory Hyperthyroidism
Background: Thyrotoxicosis is a clinical state with potentially multiple etiologies, clinical presentations, and treatments. Thyrotoxicosis is a clinical condition that results from inappropriate function of thyroid hormone in the body tissues. During the early 1950s, radioactive iodine was used as a definitive treatment method. During the last two decades, radioactive iodine has been recognize...
full textTopic: RADIOIODINE TREATMENT FOR HYPERTHYROIDISM
Results: Patients given a single dose of I of 600 MBq (16 mCi) (N = 485) had a higher cure rate (84.1%) compared with those receiving either 370 MBq (10 mCi) (74.9%, P < 0.001) or those given 185 MBq (5 mCi) (63%, P < 0.001). An increased incidence of hypothyroidism by 1 year was evident with higher doses (600 MBq: 60.4%; 370 MBq: 49.2%, P = 0.001; 185 MBq: 38.1%, P < 0.001). Binary logistic re...
full textPrimary hyperthyroidism--diagnosis and treatment. Indications and contraindications for radioiodine therapy.
Isotope therapy is one of the methods used in primary hyperthyroidism. The therapy is based on short-range beta radiation emitted from radioactive iodine. Radioiodine administration must always be preceded by pharmacological normalization of thyroid function. Otherwise, post-radiation thyrocyte destruction and thyroid hormones release may lead to hyperthyroidism exacerbation. Indications for ra...
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Journal title:
iranian journal of nuclear medicinePublisher: tehran university of medical sciences
ISSN 1681-2824
volume 19
issue 2 2011
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